Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes
نویسندگان
چکیده
منابع مشابه
Association between shortened leukocyte telomere length and cardio-metabolic outcomes.
In their meta-analysis of 27 published studies, D’Mello et al show that shortened leukocyte telomere length (LTL) is associated with 3 primary end points: myocardial infarction, stroke, and type 2 diabetes mellitus. The meta-analysis and its findings raise several fundamental issues that are worth considering. After discussing the major findings and limitations, we focus on 3 central themes: th...
متن کاملAssociation between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis.
BACKGROUND Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its associ...
متن کاملExamining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length
The mechanism of cellular aging likely involves decreased telomere length and is associated with age-related diseases such as cardiovascular disease. Metabolic syndrome (MetS) is an important risk factor for CVD. The purpose of this study was to investigate the association between LTL and MetS. We evaluated 7370 participants in the National Health and Nutrition Examination Survey (1999-2002). T...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملLongitudinal associations between micronutrient consumption and leukocyte telomere length.
BACKGROUND There are few studies on the association between nutrient intake and telomere length, which may reflect cumulative oxidative stress and indicate biological ageing. In the present study, we evaluated longitudinal associations between the consumption of micronutrients, including antioxidant nutrients and B vitamins involved in one-carbon transfer pathways, and leukocyte telomere length...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2015
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.114.000964